PLUS IS A PROPRIETARY PROCESS THAT SIGNIFICANTLY

IMPROVES CANNABINOID BIO ABSORPTION AND EFFECTIVENESS

The PLUS Process

The PLUS Process is a proprietary formula that improves the effectiveness of Cannabinoids like CBD, CBN, CBG, etc.  The PLUS Process improves the efficacy of ingested or topically applied Cannabinoids through encapsulation of the oil based cannabinoids into a water attractive shell.  

Cannabinoids are oil based and the human body is primarily water.  When used in the form of an oil, Cannabinoids like CBD, THC, etc., have very low bioavailability due in part to the combined effects of poor solubility and low permeability in the gut.  

When emulsified using the PLUS process, the solubility of Cannabinoids significantly improves bio permeability and absorption.  Overall, these properties of the PLUS Process allow more Cannabinoid particles to enter the bloodstream, creating a more powerful effect.

How the PLUS Process Works

The PLUS Process encapsulates the Cannabinoid into a core making it attractive to water. The core holds the therapeutic molecules, while the outer shell makes the particle attractive to water increasing the mobility of the encapsulated material.  

The encapsulation shell provides protection for the Cannabinoid molecule from rapid elimination or degradation when ingested or applied topically.  Cannabinoid particles encapsulated using the PLUS Process can be absorbed by cells at a more efficient rate compared to oil based ingredients alone.  Scientific studies support that particles that are encapsulated using the PLUS ingredients provide for optimal cellular absorption (increased bioavailability) through cellular endocytosis.  When encapsulated with the PLUS Process, Cannabinoid particles may provide faster onset times with improved effectiveness.

Cannabinoid Benefits

Cannabinoids are the active chemicals in marijuana and hemp.  There are over 225 different Cannabinoids now known.   These plant Cannabinoids are similar to chemicals the body naturally produces that are involved in appetite, memory, movement, and pain.

Research suggests cannabinoid oils, including tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG) and many others, may improve sleep, reduce anxiety, reduce inflammation, provide temporary pain relief, control nausea and vomiting caused by chemotherapy, kill cancer cells and slow tumor growth, relax tight muscles in people with multiple sclerosis, and stimulate appetite.

Various Cannabinoid products are marketed and sold to consumers, including beverages, tinctures, capsules, gummies, topical products, and more. Companies are producing products to help with a wide range of issues including sleep, insomnia, anxiety, low energy, concentration/focus, aches and pain, inflammation, skin rejuvenation/wrinkle reduction and overall skin health. Most Cannabinoid products are oil based which suffers from limited effectiveness in terms of their delivery to the desired cellular receptors.

Cannabinoids are Beneficial However. Their Delivery Effectiveness is Limited

Cannabinoids are oil based ingredients and the natural oil and water separation significantly impairs their effective digestion and absorption when ingested or topically applied.  Digestion and absorption of oil (often referred to as lipids) is a very extensive and chemically complicated process.  Oil based ingredients used by the body require several steps to make the material bioavailable.  The complicated process required for the absorption of oil in the digestive system substantially reduces the bioavailability and effectiveness of many other oil-based medicinal and beneficial compounds, including Cannabinoid oil.

Bioavailability and nutrient uptake of oils can be impaired by several different digestion processes including stomach acids, gut wall enzymes, bacterial enzymes, and liver metabolism.  The liver plays a major role in processing oils and converting oil particles into micelles.  These micelles are temporary compounds formed during the fat digestion and absorption process that enable general lipid digestion. Depending on the amount of oil ingested, the type of oil, and the variety of foods eaten with the oil, it can take 20 minutes to 4 hours for oil to be processed, broken down, and then digested/absorbed.  The body’s absorption process for oils is not efficient primarily due to a process called “First Pass Metabolism”.

First Pass Metabolism


First-pass metabolism (also referred to as the first-pass effect) is when the concentration of an oil is greatly reduced before it reaches systemic circulation. This concentration reduction means a decrease in absorption and bioavailability.  First-pass metabolism is a common problem that affects a wide range of medicinal and beneficial compounds including cannabinoid oils, as well as other compounds like morphine, curcumin (from turmeric), lidocaine, nitroglycerin, and more. When consumed in the form of an oil, cannabinoids have a very low bioavailability due in part to the combined effects of poor solubility and low permeability in the gut. Marinol is a THC solution in sesame seed oil, and it’s been shown only tobe about 40% absorbed in best cases.

First-Pass Metabolism Illustration

First Pass Metabolism is a detail of Lipid/Oil digestion and absorption process by the body.

When oil enters your stomach, it will not pass through the stomach lining. It moves to the small intestines where it is slowly broken down by enzymes, processed into micelles and absorbed.  A limited percentage of the material is processed into micelles rendering the bulk of the oil  ineffective.

First Pass Metabolism Effect on Cannabinoid Oils

The Bioavailability of nutrients varies widely. Oil based nutrients, including Cannabinoid oil, have a very limited bioavailability. For a wide variety of ingredients/nutrients, studies indicate you may be absorbing anywhere from 10 to 90% of the nutrients in a given food or supplement due to the First-Pass Effect. When ingesting a multivitamin/mineral, your body utilizes/absorbs anywhere from 30 to 80% of the zinc, copper, and selenium, 30 to 40% of calcium.  

For oil based ingredients/nutrients, including Cannabinoid oils, studies indicate you may absorb a mere 10 to 30%.  The PLUS Process can substantially improve oil based nutrient absorption, including Cannabinoids.

The PLUS Process Effect on Ingested Cannabinoids

Due to the First Pass Metabolism effect, when we ingest Cannabinoid oils, CBD, CBN, CBG, etc., a substantial portion of the material ingested is rendered ineffective as it is processed through the digestive system and bloodstream.   A 2012 study showed that the bioavailability of ingested CBD was around 6%, versus bioavailability of smoking CBD that was found to be around 31%.  Due to the more effective bioavailability of vaping/smoking CBD is one of the fastest and most common delivery methods of CBD.

The PLUS Process for Cannabinoids has been shown to improve bioavailability and absorption of Cannabioid oil material by creating the water attractive encapsulated shell around the oil particle. This can allow more Cannabinoids to enter the bloodstream earlier in the digestive process.  In doing so, the Cannabinoids may have a faster onset and more efficient effect.   The PLUS  Process can rival the blood levels found through Smoking/Vaping of Cannabinoids.

How the PLUS Process Can Overcome (also could use “Mitigate” here) the First-Pass Metabolism Obstacles

Research indicates the PLUS Process and ingredients can enhance the absorption of lipid soluble nutrients and natural compounds, including Cannabinoids Oils.  A water attractive shell provides for Cannabinoid oil processed with PLUS to improve bio absorption mitigating the first-pass effect.  For Cannabinoids, this conversion can allow the body to absorb much higher amounts of active Cannabinoids faster in the mouth, stomach, and small intestine.  Encapsulating the Cannabinoid oil particle in a water attractive shell increases bioavailability and onset times.  The encapsulated shell, with a fatty acid core and a water-attractive exterior, allows more efficient transportation to the intestinal microvillus. There, the fat components are released and disseminated into the cells of the digestive tract lining.

Your small intestine is lined with tiny hair-like projections called villi, which work to absorb oils, vitamins, minerals, and other nutrients from the food that passes through. Water can be absorbed in the stomach and small intestines in as fast as 5 minutes on an empty stomach.  Large quantities of water are stored in the small intestines and help in the digestive process and the absorption of nutrients. Water/oil-encapsulated material will get absorbed very quickly.

Images inside the small intestine showing tiny hair-like projections called villi.

The PLUS Process Effect on Topically Applied Cannabinoids


Topically applied Cannabinoid oils have similar absorption and effect limitations as ingested oils.  In dermatology, oil material encapsulated in a water attractive emulsion has been shown to improve dermal penetration versus only oil.  The PLUS Process conversion of Cannabinoid oil particles into a water attractive shell improves their absorption and bioavailability.  The PLUS Process provides faster and more effective topical cannabinoid products.

Research indicates oil material like Cannabinoids converted using the PLUS Proprietary Formula and Process facilitates the permeation of a variety of cellular membranes, including those in the gut, mouth, eyes, and skin.  

Vitamin E is a primary component used in the PLUS Process providing a water-soluble source of natural vitamin E. The science of the vitamin E ingredient used in the PLUS Process has been extensively studied worldwide proving it to be one of the best and safest options for emulsifiers in skincare and other personal care products.